Melissa Lambeth Kemp, Ph.D.
The Wallace H. Coulter Department of Biomedical Engineering
|Ph.D. Bioengineering||University of Washington||Seattle, WA||2003|
|B.S. Nuclear Engineering||Massachusetts Institute of Technology||Cambridge, MA||1997|
- Post-doctoral Experience
- Postdoctoral Associate, MIT Biological Engineering Division, 2003-2004; 2005-2006
CSBi/Merck Postdoctoral Fellow, 2004-2005
- Honors and Awards
- 2012, Best Graduate Research Advisor, Bioengineering PhD Program
2011, Georgia Tech Outstanding Junior Faculty Undergraduate Research Mentor
2010, CSB2 Prize for Innovative Measurement Methods, Council for Systems Biology in Boston
2009, NIH Director’s New Innovator Award
2009, Semi-finalist, Damon Runyon-Rachleff Cancer Innovation Award
2008, Packard Foundation Fellowship Award Nominee, Georgia Tech College of Engineering
2008 – 2013, Georgia Cancer Coalition Distinguished Scholar
- Research Interests
- How intracellular and extracellular environments control the transmission of cellular information is important for the understanding of cellular function. Dr. Kemp's lab investigates the mechanisms by which extracellular oxidation (by inflammation), and intracellular oxidation (such as initiated by receptor ligation) influence the ability of cells to signal. They rely upon a strong synergy between computational and experimental methods to characterize proteomic dynamics of thiol oxidation. Because of the numerous biochemical reactions involved, they use computational modeling to investigate how signaling networks are regulated in the presence of reactive oxygen species by changes in activity and/or function of redox-sensitive proteins. Experimentally, they are developing novel high-throughput techniques for the detection and quantification of reversible protein oxidation.
- Representative Publications
- Adimora, N.J., Jones, D.P., Kemp, M.L. “A model of redox kinetics implicates the thiol proteome in cellular hydrogen peroxide responses.” Antioxidant & Redox Signaling, 13(6): 731-746, 2010.
Rivet, C., Hill, A., Lu, H., Kemp, M.L. “Predicting cytotoxic T cell age from multivariate analysis of static and dynamic biomarkers”. Molecular & Cellular Proteomics, 10(3): M110.003921, 2011.
Finn, N.A., Findley, H.W., Kemp, M.L. “A switching mechanism in doxorubicin bioactivation can be exploited to control doxorubicin toxicity”. PLoS Computational Biology, 7(9):e1002151, 2011.
Finn, N.A, Kemp, M.L. “Pro-oxidant and antioxidant effects of N-acetylcysteine regulate doxorubicin-induced NF-κB activity in leukemic cells”. Molecular BioSystems, 8(2):650, 2011.
Kniss, A., Lu, H., Jones, D.P., Kemp, M.L. “A microfluidic systems biology approach for live single-cell mitochondrial ROS imaging”. Methods in Enzymology, 526: 219-30, 2013.