Michael P. Terns, Ph.D.
Distinguished Research Professor
Biochemistry and Molecular Biology and Genetics
|B.S. Biochemistry||University of Michigan||1985|
|Ph.D. Pharmacology||Pennsylvania State University||1990|
- Post-doctoral Experience
- University of Wisconsin, 1995
- Honors and Awards
- American Cancer Research Scholar
Creative Research Medal, University of Georgia
Member of New York Academy of Sciences
Distinguished Research Professor, University of Georgia
- Research Interests
- The Terns lab studies RNA-driven biological pathways with the goal of improving the understanding and treatment of human disease, and advancing biotechnology and industrial applications. Currently, they are working to delineate a series of newly identified RNA-guided immune systems that protect prokaryotes from viruses and other genome invaders - the CRISPR-Cas systems. This exciting research is leading to new ways to strengthen beneficial microorganisms that produce food, pharmaceuticals and biofuels, combat disease-causing bacteria, and prevent the spread of antibiotic resistance.
- Representative Publications
- Hale, C.R., Majumdar, S., Elmore, J., Pfister,, N., Compton,, M., Olson, S., B.R., Resch, A.M., Glover, C.V.C., Graveley, B.R., Terns, R.M. and Terns, M.P. (2011) Essential features and rational design of CRISPR RNAs that function with the Cas RAMP module complex to cleave RNAs. Molecular Cell, 45:292-302.
Terns, M.P. and Terns, R.M. (2011) CRISPR-based adaptive immune systems. Current Opinion in Microbiology, 14(3)321-327.
Carte, J., Pfister, N.T., Compton, M.M., Terns, R.M. and Terns, M.P. (2010) Binding and cleavage of CRISPR RNA by Cas6. RNA, 16(11):2181-8.
Hale, C., Zhao, Peng, Z, Olson, S, Duff, M.O., Graveley, B.R., Wells, L., Terns, R.M. and Terns, M.P. (2009). RNA-Guided RNA Cleavage by a CRISPR RNA-Cas Protein Complex. Cell, 139(5):945-956.
Carte, J., Wang, R., Li, H., Terns, R.M. and Terns, M.P. (2008) Cas6 is an Endoribonuclease that Generates Guide RNAs for Invader Defense in Prokaryotes. Genes & Development. (22):3489-3496.