Robert Woods, Ph.D.
Biochemistry and Molecular Biology
|B.Sc. Engineering Chemistry||Queen's University||Canada||1985|
|Ph.D. Computational & Carbohydrate Chemistry||Queen's University||Canada||1990|
- Post-doctoral Experience
- 1990-1991 Postdoctoral Fellow, Laboratory for Molecular Modeling, The University of North Carolina
1991-1994 Postdoctoral Fellow, Glycobiology Institute, The University of Oxford, United Kingdom
- Honors and Awards
- 1985-1986 Queen's University Graduate Fellowship
1986-1987 Province of Ontario Graduate Studies Scholarship
1987-1990 National Sciences and Engineering Research Council of Canada,
NSERC Graduate Scholarship
1990-1992 Natural Sciences and Engineering Research Council of Canada,
NSERC Postdoctoral Fellowship
1992 University of Oxford, Lockey Bequest
1999 Member of Group Study Exchange Program to Argentina, Athens West Rotary Club
- Research Interests
- Research in the Woods group examines the relationship between
carbohydrate structure and biological recognition. Areas of particular
interest include carbohydrate recognition as a mechanism for pathogen
adhesion and infection; characterizing carbohydrate antigenicity in
immunological events; and the development of carbohydrate-specific
reagents for the detection of carbohydrate-related disease markers.
The research combines advanced computational 3D structure simulations
with experimental methods, such as molecular biology, surface plasmon
resonance, flow cytometry, and NMR spectroscopy.
- Representative Publications
- Yongye, A.B., J. Gonzalez-Outeriño, J. Glushka, V. Schutlheis, and R.J. Woods. 2008. The Conformational Properties of Methyl a-(2,8)- di/trisialoside. Implications for anti-Neisseria meningitidis Vaccine Design. Biochemistry 47, 12493–12514.
Fadda, E. and R.J. Woods. 2010. Molecular Simulations of Carbohydrates and Protein-carbohydrate Interactions: Motivation, Issues and Prospects. Drug Disc. Today 15, 596-609.
Kadirvelraj, R., O. Grant, I.J. Goldstein, H.C. Winter, H. Tateno, E. Fadda, and R.J. Woods. 2011. Structure and Binding Analysis of Polyporus squamosus Lectin in Complex with the Neu5Acα2-6Galβ1-4GlcNAc Human-type Influenza Receptor. Glycobiology, 21(7), 973-984.
Fadda, E. and R. J. Woods. 2011. On the role of water models in quantifying the standard binding free energy of highly conserved water molecules in proteins: the case of Concanavalin A. J. Comput. Theor. Chem. 7, 3391–3398.
DeMarco, M.L. and R.J. Woods. 2011. From Agonist to Antagonist: Structure and Dynamics of Innate Immune Glycoprotein MD-2 upon Recognition of Variably Acylated Bacterial Endotoxins. Molecular Immunology, 49, 124-133.